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MONTGOMERY. 
[Vol. XV. 
stain in the same manner as those contained in the cytoplasm. 
But occasionally from one to three of the larger globules (Fig. 
267) in the nucleus stain much more intensely than the others, 
though intermediate degrees of staining are to be found between 
these largest, most deeply colored ones and the smaller, less 
deeply stained ones ; so that there can be no doubt of the 
genetic relation of the two kinds. By staining with eosin 
these largest yolk globules in the nucleus stain almost or quite 
as deeply as the nucleolus itself, so that at first I mistook them 
for nucleoli ; but that they are chemically metamorphosed yolk 
globules and not nucleoli is shown, even leaving aside the fact 
that all intermediate forms may be found between them and 
the less deeply staining globules of the cytoplasm, by the fact 
that vacuoles are never found within them. By the Ehrlich- 
Biondi staining method no color differentiation was to be 
obtained for the larger and smaller yolk globules of the nucleus. 
But nevertheless I would think that these large yolk globules 
(or accumulations of such globules) which have been taken 
into the nucleus from the cytoplasm and there have undergone 
some degree of chemical change, possibly stand in genetic 
connection with that body which is apposed to the nucleolus 
in the larger germinal vesicles, and which has been described 
in the preceding paragraph. 
Chromatin. —We found the chromatin in the primitive peri¬ 
toneal cells and in the youngest ovogonia to be arranged in the 
form of granules (Figs. 250-254). In the following mitoses it 
is arranged in the form of a spirem, then of chromosomes, and 
again of a spirem (Figs. 255-261). Just after the conclusion 
of the spirem stage (of the metaphasis) it comes to lie in a 
more or less dense mass around the nucleolus, this mass 
appearing to be composed of a reticulum of short fibers (Figs. 
263-266, 270, 271, 278). In all these stages the chromatin is 
marked by its deep blue staining with haematoxylin. After 
the last stage described it gradually departs from the close 
vicinity of the nucleolus and becomes evenly distributed 
throughout the nucleus. But when it has thus become diffused 
it does not stain with haematoxylin as before, but appears in 
the form of a very large number of minute microsomes, which 
