687 
THK ALFORT SCHOOl., 1839-40. 
These facts^ combined with some other undoubted ones, of the 
transmission of glanders from man to the horse, render this sad 
truth too evident, that communicated acute glanders is no longer a 
malady peculiar to the horse. 
As to the contagiousness of acute glanders by cohabitation with 
animals different from the horse, MM. Renault and Bouley can give 
no positive opinion. The experiments in which they have been 
engaged have been attended only by negative results. 
A serious question remains to be solved,—What is the nature 
of acute glanders 1 Is it a malady of a specific kind, as variola or 
syphilis; or is it only one of the forms of purulent infection 1 The 
following are some of the elements, grounded on experiment, which 
may enable us to arrive at a definite solution of this pathological 
problem. 
Pus, in small quantities, dissolved in distilled water and filtered, 
has been injected into the veins of many horses. In some of these 
animals an intense fever has supervened between the first and the 
third day, and has continued until the seventh or eighth ; then, by 
little and little, the febrile symptoms have subsided, and, at the 
fifteenth day, there has no longer remained any symptom of disease. 
These animals being destroyed by venesection, there have been 
found in the lungs and in the spleen numerous abscesses, perfectly 
isolated by the firmness of their surrounding tissues. 
This purulent injection has determined in other animals an in¬ 
tense febrile re-action; and from the third to the fifth day, the ordi¬ 
nary time of the incubation of acute glanders, whether spontaneous 
or generated, the symptoms of this malady have appeared with 
their characters well marked, and the animals have died between 
the tenth and the twentieth day. 
Examination after death has shewn in the nasal cavities, the 
lungs, the spleen, and the articulations, all the characteristic lesions 
of acute glanders. 
In order to remove every doubt with respect to the nature of 
this affection, in some degree an artificial one, we have inoculated 
some sound animals with the matter discharged from the nostrils of 
others that have become diseased by a purulent injection, and acute 
glanders has been the result. 
In another case, the introduction of pus into the veins of a 
healthy animal, has had the remarkable result of producing an 
abscess in one of the fore legs, with suppuration of the articulations 
and tendinous sheaths. Some abscesses were found in the lungs, 
but the nasal cavities were perfectly sound. 
There is yet another remarkable circumstance, and well worthy 
of attention, as a consequence of the injection of pus into the veins,— 
there are sometimes developed abscesses in the lungs ; sometinu's 
