TOXICOLOGY. 
520 
iron, dissolved in six quarts of water. The animal did not seem 
to be in the least degree affected until the following morning. 
By noon he was exceedingly dejected, and had evident colicky 
pains. On the following night diarrhoea came on, and was almost 
constant; at three o’clock in the morning he fell on his litter, with¬ 
out the power of rising again ; and at five o’clock in the morning 
he died. The same lesions were found, but in an aggravated 
degree. The sulphate of iron seemed to increase the activity of 
the poison. 
CASE III. 
I would not abandon the arseniate. On Nov. 7th, at 8 a.m. 
I administered two ounces of it to an old horse, more than usually 
tall, and at the same time four pounds of the hydrate of the peroxide 
of iron—thirty-two times as much of the antidote as of the poison. 
This horse also appeared to be unaffected for twenty-eight hours: 
symptoms of poisoning then ensued, and at the end of fifty-four 
he died, after having suffered dreadfully. The same lesions were 
observed. 
CASE IV. 
I determined to give one more trial to the sulphate of iron, 
thinking it possible that I might have given it in too great a 
dose. On Nov. 10, at 7 a.m. I gave two ounces of the poison 
to a small horse, and at the same time eight ounces only of the 
sulphate of iron, dissolved in four quarts of water. The horse 
died at the expiration of fifty-two hours, and the lesions were 
the same. 
My other experiments refer to the power of the hydrate of 
the peroxide of iron on arsenious acid. The experiments of 
MM. Orfila and Lesueur had shewn the necessity of giving very 
great doses of the antidote. I therefore began with small doses 
of the poison, such only as I thought were sufficient to destroy 
life, and my first trials were with the determining what quantity 
was necessary for that purpose. 
CASES V & VI. 
"Nov. 9^A, 1834.—I gave four drachms of arsenious acid to a 
small English horse, 9 or 10 years old, and which had been kept 
fasting during twenty-four hours. This dose of the arsenic 
not having produced derangement in any function, I on the 
15th, or six days after the first dose, gave an ounce of the same 
substance. No effect being produced by this, I destroyed the 
horse on the 23d, apparently in good health, and after a very 
careful examination, 1 could not discover any lesion which I 
could attribute to the action of the poison. 
