TOXICOLOGY. 
523 
mucous membrane of the right sac was slightly thickened. The 
pylorus of the stomach, and the duodenum at its origin, had a 
reddish purple hue, and the mucous membrane was double its 
natural thickness. Through the whole extent of the small intes¬ 
tines there were red, marbled patches—evident traces of great 
inflammation. This lesion disappeared towards the csecum. This 
last intestine was sound; but in the colon, on the contrary, in its 
sus-sternale portion, there was an erosion of an oval form, six 
inches long and three wide: the mucous membrane was com¬ 
pletely destroyed, and the muscular one disorganized and thick¬ 
ened, and a yellow infiltration separated the muscular mem¬ 
brane from the serous one. The lungs, the heart, and the brain, 
were sound. 
It was evident that the antidote, although administered at the 
same time with the poison, did not act with so much activity in 
this as in the other cases : it is yet impossible to deny its efficacy, 
since the animal that was the subject of this experiment w^as 
not destroyed until the nineteenth day after he had taken the 
poison, and not having exhibited any symptom of illness, although 
every horse that had taken two ounces of the arsenious acid, 
without the antidote, had died on the second or third day. 
Hitherto the power of the hydrate has been considered when 
given at the same time with the poison; but it can be seldom 
thus administered. An inquiry of much greater importance lies 
before us—until what time after the ingestion of the poison may it 
be administered with success? 
CASE XV. 
Jan. Ath, 1835.—Two ounces of white arsenic, mixed with 
half a pound of honey, w'ere given to an old and strong horse at 
8 o’clock, A.M. ; and two hours afterwards the counter-poison 
w'as given in the usual quantity. This animal was killed on 
the 12th, without exhibiting any symptom of illness. There 
were two lenticular erosions on the lining membrane of the 
right sac of the stomach ; traces of slight inflammation in the 
small intestines and at the point of the csecum, and small 
ecchymoses in the left ventricle of the heart. It was evident 
that the antidote, although not administered until two hours 
after the ingestion of the poison, had almost entirely neutralized 
its power. 
CASE XVI. 
Jan. Qth .—I administered the poison to an old middle-sized 
horse, and gave the antidote four hours afterwards. This animal 
remained apparently w’ell, when it w'as destroyed. A great 
