322 ON THE USE OF CANTHARIDES IN GLANDERS. 
was an obstruction in the jejunum which effectually prevented 
the passage of the thinnest liquid through that gut; consequently 
the stomach and duodenum were greatly distended, and the ileum, 
ccecum, and colon nearly empty. In the centre of the jejunum, 
and for about eighteen inches in length, the gut was enormously 
distended, and black in the extreme; it was slightly contracted 
at either extremity of the diseased portion, but of a healthy 
colour. I removed the diseased part, and, on cutting through 
the peritoneal coat, a large quantity of blood escaped, of a 
dark colour. I then perceived that the cause of all the mis¬ 
chief was an extravasation of blood between the peritoneal and 
muscular coats of the intestine ; and so great was the pressure 
of the coagulated blood against the internal coat of the gut, 
that I could not force water through the passage. The blood¬ 
vessels in the omentum, contiguous to the affected portion of the 
jejunum, were very much enlarged ; the other intestines appeared 
healthy, aswas also the kidneys and urinary organs. 
ON THE USE OF CANTHARIDES IN GLANDERS. 
(A Letter from Mr. Charles C. Brett, V. S., of Bletchingly , 
to Mr. Vines.) 
Sir, 
I have perused your work on Glanders with considerable 
pleasure, and have the satisfaction of reporting to you a case I 
have had in hand, wherein your mode of treatment has been 
most completely successful. 
A coach mare, five years old, with acute glanders, was con¬ 
demned for the hounds. * Her owner (the proprietor of the 
Godston coach), however, was induced to put her under my care 
on the 16th of June last, and I discharged her, restored to perfect 
soundness, on the 30th of July following. 
From a few days after the first exhibition of the cantharides, 
the mare’s tone of stomach and spirits gradually began to im¬ 
prove ; she progressively gained flesh, and the ulcers on both 
sides the septum began to die away, and the tumefied glands to 
subside. I fed her, as you direct, on the most nutritious diet, 
and in the most bountiful profusion, but her appetite kept pace 
with the supply of food. I placed her at large in the bay of a 
barn, where she had a plentiful admission of fine fresh air, and 
administered the cantharides daily (secundum artern), in doses of 
five and six grains. 
