TREATED WITH QUININE. 
473 
full length of his halter: this shivering lasted from an hour and a 
half to two hours, and was followed by great depression of 
spirits; and it was not until some hours after that the appetite 
returned. 
From the examination I made of this animal when he was 
brought to me, I could not perceive any symptoms of disease : it 
was not until the next day, between ten and eleven o’clock in the 
morning, that I recognized the unequivocal tokens of intermittent 
fever. The third day, at the same hour, the animal was seized 
with another fit. At eight o’clock on that evening I administered 
eight grains of sulphate of quinine ; at midnight, eight grains 
more; at four in the morning, another eight grains; and three 
or four hours afterwards, another eight grains; which I com¬ 
pounded in the following manner:— 
Sulphate of quinine.eight grains 
Common distilled water . eight ounces. 
I dissolved the sulphate in the water by means of a glass pestle 
and mortar; and, to perfect the solution, I put in a few drops of 
sulphuric acid, which has the property of dissolving all sul¬ 
phates. 
On the fourth day, between ten and eleven o’clock, the fit was 
shorter and less violent than before. The same medicine was 
given as yesterday, and at the same hours. 
On the fifth day, the febrile symptoms were less apparent; 
the animal shewed only a little uneasiness. The same medicine 
was continued. 
On the sixth day, the morbid symptoms completely ceased : 
nevertheless, I continued to adminster the sulphate of quinine, 
during nine days, in the following doses, in the morning and 
fasting:—On the first three days, eight grains each morning ; on 
the three next, four grains; and on the three last, only two 
grains each morning. The fifteenth day the horse was returned 
to his owner, perfectly cured. 
Case II.—About the middle of September, 1828, I was con¬ 
sulted by M. Sevin, farmer at La Valie, about a draught horse 
of the Picardy breed, and aged ten ; of a weak constitution ; and 
who for the last five or six days had every day, at the same hour 
(three o’clock in the afternoon), the following symptoms:—He 
would suddenly cease to eat, become dull, hang his head, go 
back to the full length of his halter, and soon be seized with 
shiverings of the whole body. He usually continued in this 
state about two hours, after which these symptoms progressively 
disappeared. I examined this horse when he was brought to 
me, and his appearance was that of an animal in perfect health. 
3 s 
VOL. V. 
