477 
TREATED WITH QUININE. 
lasted during nearly two hours. As now, and through the whole 
of the remaining illness, the symptoms were almost the same as 
those I mentioned in the former cases, I shall pass them over in 
silence. 
The thirtieth day, at nine in the morning, the shivering came 
on, and lasted two hours and a half or three hours, and a hot 
fit succeeded. That state of uneasiness and pain which yester¬ 
day preceded the shivering, did not appear to-day. 
The thirty-first day, at the same hour, there was another fit, 
not preceded by uneasiness. In the evening of this day, at six 
o’clock, I gave fourteen grains of sulphate of quinine in a pint 
of water, with the addition of a few drops of laudanum, as a clyster. 
Four hours afterwards I gave another clyster, composed in the 
same manner; at tw r o in the morning, a third; and four hours 
afterwards, another. 
The shivering was less, the mouth not so hot, the respiration 
in its natural state, the pulse full without being too quick, and 
the artery compressible. The animal was continually searching 
for something to eat. 
On the thirty-second of the disease, I gave fifty-six grains of 
the sulphate of quinine in four clysters, at the same hours as 
before. All the morbid symptoms completely disappeared. For 
nine days I continued to administer the sulphate of quinine in 
the morning fasting to this horse, as I had done to the former 
ones. 
From this time the animal has been perfectly well. 
Note .—Care must always be taken, when w r e wish to act on 
the mucous membrane of the rectum, to empty this intestine by 
means of one or two simple clysters; and as soon as the last 
has been returned, to give the intended clyster, made with as 
little water as possible, and with the addition of a few drops of 
laudanum, to prevent gripes: for to succeed in this treatment, 
it is absolutely necessary that the clyster should not be returned, 
at least for a considerable time after it has been administered. 
I also think that the dose of sulphate of quinine might be aug¬ 
mented without inconvenience, whether given by the mouth or in 
clysters ; and we might thus succeed in arresting the fever in its 
earliest stage. 
PS. Since writing the above observations, I have had oppor¬ 
tunities of seeing several horses labouring under the same dis¬ 
ease : these animals have all been treated with sulphate of 
quinine, and were all perfectly cured. 
( Recueil de Med. Vet.) 
