GLANDERS IN THE HUMAN BEING. 
149 
complain of much pain in the head, and became delirious, to miti¬ 
gate which leeches were applied to the forehead : he then spoke of 
wandering and acute pains every where, indicating some rheumatic 
affection; and a tumour appeared on one of the metacarpals, 
and another on one of the metatarsals, seemingly of a gangrenous 
nature. The pain in the head would again return, attended by 
delirium, so that he was compelled to be strapped on his bed; 
and, all the while, his flesh was wasting and his strength diminish¬ 
ing, and, in fact, he was evidently sinking. 
Five days, however, before his death, the site of the leech- 
bites assumed a purple, puffy ap]>earance—the approach of 
sloughing was indicated ; and similar soft tumours appeared on 
the back part of the head, and rapidly increased until the pos¬ 
terior part of the head assumed a strangely swollen and unnatural 
appearance; at the same time some scattered large globular pus¬ 
tules began to arise on the neck, and there was occasional dis¬ 
charge from the right nostril, which was thin, yet somewhat ad¬ 
hesive ; of a yellowish brown colour, and exceedingly offensive. 
A smaller discharge, but not so frequent, appeared also from the 
left nostril. The man now began to rally a little, and could be 
induced to enter into a somewhat unconnected conversation. 
The tumours increased in number and size, but were still pro¬ 
miscuously scattered, and many of them were seen on the arms; 
and on some parts of the arms and more of the legs, there were, 
on the course of the principal lymphatics, slight elevations of 
the integument, which, on pressure, seemed to indicate the 
presence of a fluid; and some of which began to assume a red and 
even purple hue. 
The resemblance between these new appearances and two cases 
of supposed inoculation with the matter of glanders, which had 
occurred in this Hospital in 1829, under Dr. Elliotson and Dr. 
Roots, struck Mr. Stone, the assistant apothecary of the Hospital, 
and, the former gentleman happening to be in the Hospital, and 
the physician by whom the patient had been admitted not 
having to attend again until two days had passed, Mr. Stone 
requested him to see the man. Dr. Elliotson immediately con¬ 
firmed Ml- Stone’s diagnosis; and, on questioning the poor fellow. 
