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Treatment in Piroplasmosis 
each day were negative. On the fifth day the animal showed clinical 
symptoms, temperature 104’8°, pallid mucous membranes, urine highly 
coloured, and the dog refused all food. Although no parasites could be 
found after a very careful search the writer decided to inject 20 c.c. of 
Trypanblue solution. The animal made a slow but complete recovery 
after the formation of a large abscess at the site of injection. 
This case is interesting, as, although no parasites were ever found 
in the peripheral blood, the animal responded to the drug. In this 
connection the writer has encountered a case in which parasites were 
never found in the peripheral blood, but were seen in great numbers in 
kidney smears after the animal’s death. 
Case. IV. Subject. Crossbred bull terrier, weight about 30 lbs., * 
property of writer. 
Developed typical “ biliary fever” in Pondoland in November, 1911, 
showed marked clinical symptoms and a fairly heavy infection of 
parasites in the blood. Was injected with 20 c.c. of a 2Yo solution and 
made a good recovery after the formation of an abscess. The animal 
spent part of the next summer (tick season) in Pondoland and the 
remaining portion in a practically tick-free locality in the Karroo. In 
October 1913 the subject was taken to a very virulent biliary fever 
area near Cape Town, and in about twenty days developed all the 
clinical symptoms of the disease,—temperature 105° F., coloured urine, 
marked pallor of the nrucous membranes, loss of appetite—although 
parasites were never found in the peripheral blood after a prolonged 
search in several films. 20 c.c. of a 2“/o solution were injected and the 
animal recovered satisfactorily. This case is interesting as showing 
that an animal can become infected a second time after an interval of 
two years, and that Trypanblue is efficacious in this second attack. 
Equine Piroplasmosis, Biliary Fever (Nuttallia equi). 
The writer was fortunate in being stationed for three years in a 
locality—East Griqualand—where “raw” horses and mules introduced 
from nou-biliary fever areas generally developed the disease within six 
weeks of their arrival during the tick season. Biliary Fever in the 
horse is, of course, amenable to treatment by other drugs {e.g. calomel 
and chloride of ammonium), but the constant dosing three times a day 
for a week, which this treatment generally involves, is dangerous and 
inconvenient in all animals, and quite impracticable in the case of wild 
