A. Goodall 
65 
or uotrained ones. On this account the writer decided to give Trypan- 
blue a trial and he has been more than satisfied with the results 
obtained. So satisfactory has the treatment been in practice, and such 
is the confidence of the public in it, that many horses and mules are 
now brought into the district irrespective of the part they were bred in, 
which would have been considered a very risky proceeding a few years 
ago. This is a point of great practical importance to a community 
which has to depend almost exclusively on equine transport. 
The writer has always injected the drug in large doses (200 c.c.) 
into the jugular vein of the horse and mule, and whilst taking precau¬ 
tions not to introduce air if possible, has been forced to the conclusion 
(through being compelled to use faulty syringes etc.) that the danger of 
injecting a little air into the vein has been greatly exaggerated. When 
ordinary aseptic precautions are observed the writer has never seen any 
ill effect follow the injection, beyond an occasional harmless oedematous 
swelling along the jugular furrow and on to the chest. 
Two Tyjncal Gases. 
Case I. Subject. Carriage Horse, four years old. 
This animal was brought to East Griqualand from a non-biliary 
fever area, and five weeks after its arrival it developed clinical symptoms 
of biliary fever (loss of appetite, mucous membranes jaundiced, urine 
stout-coloured, temperature 103°-104'5° F.). Blood smears showed 
marked anaemia and the presence of a few parasites, although it must 
be confessed that the author has nearly always experienced great 
difficulty in finding parasites in this disease in the horse and mule, in 
spite of the fact that all the clinical signs of the malady are present. 
200 c.c. of a 2'’/o solution were injected into the jugular vein and the 
animal made an uninterrupted recovery, the temperature subsiding 
after twenty-four hours and the appetite slowly returning. 
Case II. Subject. Imported North American Mule, aged six 
years. 
This animal was brought almost direct off the ship into East 
Griqualand and was therefore very susceptible to the disease. Three 
weeks after arrival it developed biliary fever, but it had been noticeably 
ill for four days before it was seen by the writer. When examined it 
showed very marked clinical symptoms —pallid mucous membranes, 
temperature 104*8° F., hurried respiration, staggering gait, and generally 
Parasitology vii 5 
