256 
Negri hoelies 
find typical Negri bodies and these two were proved to be rabid 
experimentally. In seven, the experimental results were negative both 
as regards the microscopical and the animal test. In the remaining 
three, the animal test was positive, whilst microscopically minute bodies 
(J to I fjb) resembling Negri bodies were seen. In order to clear up this 
last point she examined the cerebellum and hippocampus major of 
normal cats and those which had died of di.seases other than rabies. 
She found that these parts in the cat, both in the normal and diseased 
state may exhibit forms resembling typical Negri bodies. In conclusion 
she states that, to be certain of the diagnosis of rabies in this animal 
it is necessary to carry out the experimental tests as well as the 
microscopic. Pace (1904) has found Negri-like bodies in three persons 
who died of old age, cerebral embolism, and aortic disease respectively. 
Babes (1906) had described, in cases dying from arsenical poisoning, 
bodies very analogous to Negri bodies in the spinal ganglion cells. 
Carlos Franca (1906) has pointed out that the presence of Negri 
bodies is one highly correlated, with rabies and that it is a condition 
almost pathognomonic for this disease. But he states that on the one 
hand they are not invariably jiresent in the nervous system of rabid 
animals and on the other may occasionally be seen in men and animals 
who have not succumbed to this infection. A great deal of work has been 
done on bodies which in many respects resemble those met with in 
rabies. These occur for example in Variola, Chicken pox, Molluscum 
contagiosum. Trachoma etc., and are named variously after their dis¬ 
coverers (Guarnieri, Prowazek etc. or in a way to suggest a parasitic 
nature). The term Chlamydozoa (Prowazek) is very generally used 
as a family name for this group of supposed organisms. A general 
description of them is given by Hartmann (1910) which we may re¬ 
produce here. 
“To begin with large granules are met with in the infected cell for 
the most part near the nucleus (‘initial granules’—first described by 
Herzog and Lindner), which in division give rise to dumb-bell-shaped 
figures. Later these granules are surrounded by reaction-products 
(nucleolar substance). By continued division a large number of smaller 
granules are produced—the so-called ‘ elementary granules.’ These 
latter together with the extruded reaction-products of the nucleus form 
a ‘cell-inclusion’ which is usually closely applied like a cap to the 
nucleus. Through the pressure of these elementary granules, regarded 
as possessed of the properties of parasites, the cell is stimulated to 
extrude a reaction-product which envelops them like a mantle. On this 
