H. W. Acton and W. F. Harvey 
269 
(iii) When the nucleolar particles leave the nucleus, an interaction 
occurs between them and the cytoplasm and so Negri bodies are 
formed. 
(iv) The manner and the extent of the nucleolar discharge and the 
degree of cytoplasm reaction vary with different animals and thus the 
variations in structure and size of these bodies are accounted for. 
(v) The iron staining granules in the Negri body are fragmented 
particles of nucleolar matter, whicli still retain the original iron staining 
character of the nucleolus. 
(vi) Although these bodies are not truly specific for rabies yet 
their presence in marked numbers is very closely associated with this 
disease, probably in the same way as the Gnarnieri bodies are for 
vaccinia (Ewing 1905) and the Plimmer’s bodies for carcinomata 
(Borrel 1907, Farmer and others 1906, Greeuough 1905). These latter 
bodies have already been regarded as being formed similarly to the 
structure known as the archoplasmic vesicle of a cell. 
(vii) Thus we maintain that whatever the parasite for rabies may 
be it has not been demonstrated microscopically. 
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