272 
Negri Bodies 
distinct from the cell-inclusions in question. These organisms, by their 
pathogenic action on the cell, upset the relations of nucleus and cytoplasm 
and cause the nucleus to extrude nucleolar substance into the cell, thus 
producing the characteristic cell-inclusions. The parasites themselves 
become enveloped in these lauclear extrusions, as in a mantle, hence 
Prowazek proposed for these organisms the name Chlamydozoa. 
The cell-inclusions must therefore be distinguished from the (alleged) 
true parasites; the names Gytoryctes, Neuroryctes, etc. must not be 
taken as denoting genera of Chlamydozoa. Gytoryctes and Neuroryctes 
are to be regarded as pseudo-parasites, consisting of masses of nucleolar 
substance extruded under the provocation of the true parasites, the 
minute, almost ultra-microscopic Chlamydozoa. Capt. Acton and 
Major Harvey do not seem to have grasped this difference, since on 
p. 256 they say “The term Chlamydozoa (Prowazek) is very generally 
used as a family na.me for this group of supposed organisms,” i.e. for 
Guarnieri’s bodies, etc., regarded as of parasitic nature. On the contrary, 
the “Chlamydozoa” theory is_in direct antagonism to the view that 
Guarnieri’s, Negri’s, Mallory’s, etc., bodies are of parasitic nature; it 
rests entirely on the view that they are nucleolar extrusions. This 
memoir, then, takes the question of hydrophobia to stage (3), and leaves 
stage (4) untouched. 
