Urethra I Sp iroch aetosis 
from these spirochaetes was not observed but I think it may be 
presumed as other scales were seen containing chains of granules that 
had all the appearance of having been formed in spirochaetes. The 
next stage resulted in the formation of masses of coccoid bodies in the 
epithelial scales and this was probably brought about by the multiplica¬ 
tion of the original granules developed in the spirochaetes since scales 
were seen showing every degree of infection from a single chain of 
coccoid bodies to great masses of the same organisms filling up practically 
the entire cell. The granules elongated forming first bacillary bodies, 
Fig. III. Spirochaetes in a urethral cell showing some of the stages of development from 
the coccoid granule. A few bacteria are also shown. Drawn from a stained prepara¬ 
tion with the aid of an Ahbc-Zeiss camera lucida. Magnification x 2000. 
then spirilla, then typical spirochaetes which grew and eventually 
escaped out of the cells and became free-hving organisms. The phase 
of development would seem to resemble very closely that described 
by Hindle (1911) as occurring in ticks infected with S. gallinarum, 
but differed from it in this respect, that the spirochaetes remained 
within the cells until they had assumed the normal foriji instead of 
escaping in the state of short spirilla. 
In the foregoing account I have endeavoured to indicate the actual 
facts observed before proceeding to outline the development which 
