56 
EXPERIMENTAL DRUG TREATMENT OF EAST 
COAST FEVER OF CATTLE. 
By GEORGE H. F. NUTTALL, F.R.S. 
{From the Quick Laboratory, University of Cambridge.) 
(With 1 Chart.) 
The results obtained in the treatment of East Coast Fever have 
been uniformly negative. Nevertheless it appears desirable to pubhsh 
the records of 18 experimental cases which we have treated with various 
drugs, since the negative evidence afforded may help other workers in 
the search for the remedy which we must hope will ultimately be found. 
Trypanblue was found to be ineffective by Nuttall and Hadwen 
(v. 1909, Parasitology, ii. p. 190), in one experiment the dye “exerted 
no effect whatsoever on the parasite.” The record and chart of the 
case accompanies the paper by Nuttall, Fantham and Porter (9. ii. 1910, 
Parasitology, ii. pp. 329, 331, 332). A cow was infected by means of 
Rhipicephalus evertsi adults, she showed fever on the 14th day, and a 
few parasites were found in her blood 20 days after the ticks had been 
placed upon the animal. The trypanblue was given intravenously on 
the 21st (200 c.c. of 1 % solution), 22nd (200 c.c. of 2 % solution) and 
23rd day (100 c.c. of 2 % solution), but the number of parasites steadily 
increased until the animal died. Negative results were subsequently 
obtained in a field trial conducted in South Africa. We have shown 
that trypanblue is an excellent remedy for piroplasmosis in dogs and 
cattle, and it has been found effective- in biliary fever in horses. As 
the question is frequently asked “What is trypanblue?” I herewith 
append the formula (C 34 H. 24 NgOi 4 S 4 Na 4 ; the tetrazo compound of 
toluidine and amidonaphtholsulphonate of sodium). 
The drugs used in the experiments herein recorded were the following: 
I. Congo red (“concentrated,” obtained from Messrs Levinstein, 
Ltd., Blackley, near Manchester). It was used once, 70 c.c. of a 
