58 Drug Treatment of East Coast Fever of Cattle 
V. Arsacetin (sodium-p-acetyl-aminophenylarsinate-acetylarsanilate. 
Obtained from Farbwerke vorm. Meister Lucius und Briining, Hoechst 
a. M.) was given in doses of 2 to 5c.c. of a 5 % solution, intravenously 
on seven alternate days. Treatment began on the day after the parasites 
appeared in the animal’s blood. The drug exerted no effect, as wall be 
seen by reference to the protocol on p. 65. 
VI-VII. Soamin (sodium-para-amino-phenylarsonate. Obtained 
from Messrs Burroughs Wellcome and Co.). In Exp. VI 2-5 grammes 
dissolved in 12-5 c.c. of hot water and injected intramuscularly, whilst 
warm, on seven days. Treatment began on the day when parasites 
first appeared in the calf’s blood. In Exp. VII a 2 % solution was 
injected intravenously in doses ranging from 3 to 13 c.c. following on 
the injection of 2 to 4 c.c. of a solution of eosin and sodium bicarbonate 
a grain of each per c.c.). The treatment began on the fifth day after 
the parasites appeared in the calf’s blood. In both experiments the 
drug exerted no influence on the progress of the disease. (See protocols, 
. pp. 66, 67.) 
VIII. “ 606” : a single dose of 2 grammes was injected intravenously 
on the third day after the parasites appeared in the cow’s blood. The 
drug did not produce any visible effect on the parasites and the animal 
died of East Coast Fever within 48 hours. (See protocol, p. 68.) 
IX. Emetine hydrochloride, 1 % in NaCl solution was injected 
intravenously in doses ranging from 1 to 10 c.c. on nine successive days, 
beginning on the second day of the appearance of parasites in the calf’s 
blood. The drug did not affect the course of the disease, the number 
of parasitized corpuscles in the peripheral blood mounted steadily 
until the am’mal died. (See protocol, p. 69.) The drug was used 
because of the favourable reports relating to its curative action in 
Amoebiasis. 
X. Mercury salicylate, 1 % in 0'8 % NaCl solution was injected intra¬ 
venously in doses ranging from 4 to 20 c.c. on nine days. Treatment was 
commenced two days before the parasites appeared in the animal’s 
blood. The drug exerted no retarding effect upon the progress of the 
disease. (See protocol, p. 70.) 
XI. Mercury succinimide (Hg[C2H4(C02)N]2) in 3 % solution was 
injected intravenously in three doses of 2, 4 and 3 c.c. in as many days, 
beginning on the day when the first parasites appeared in minimal 
