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AbderJialden's Reaction 
Application to the study of disease. 
The application of this reaction for the diagnosis of pregnancy is 
sufficiently well known, but it may also be employed for the study of 
disease. If a certain organ of the body is diseased, as a result of the 
degeneration of its tissue, some of its albumins wdll enter the blood 
and induce the formation of ferments which act on these particular 
albumins. These ferments seem to be specific in their action since they 
only digest those albumins which called forth their production. For 
example, if the liver of a particular animal is diseased, liver albumins 
are set free in the blood circulation by the breaking down of liver-cells 
and the subsequent liberation of their contents. Specific ferments 
would then be produced in the blood, which can digest these liver 
albumins, and by collecting some of the serum from such an animal 
and mixing it with liver tissue from the same species, prepared in the 
manner described above, it is possible to detect the presence of these 
ferments, as the liver substance is broken down into dialysable peptones, 
or amino-acids. 
When an animal is infected udth any pathogenic micro-organisms, 
in most cases ferments are produced which digest them, and thus it is 
possible to detect what kind of micro-organism is infecting any particular 
animal by the changes in its blood. 
This reaction seems likely to be of value in the diagnosis of protozoal 
infectious, because in these cases the ordinary immunity reactions are 
very variable and uncertain. In the case of spirochaetosis, trypano¬ 
somiasis and sarcosporidiosis, one of the authors (Gozony, 1914) 
has obtained very favourable results by the application of Abderhalden’s 
reaction, and accordingly we have examined the blood from animals 
suffering from another class of protozoal infection, in order to see 
whether similar results could be obtained in these cases. 
East Coast Fever {Tkeileria parva). 
Experiments were made with the serum from calves infected with 
East Coast Fever. The animals were infected by feeding infected 
ticks (Rhipicephalus appendiculatus) on them. After an incubation 
period of about eleven to twelve days a calf shows a rise in temperature ; 
about five days later parasites appear in the peripheral circulation, and 
