220 
Tryposafrol 
Erfolge”) and success has followed the treatment of mules and donkeys 
suffering from trypanosomiasis in German East Africa and Cameroon. 
These claims are bewildering and the manner in which they are presented 
compels criticism. 
That the authors are inaccurate in some of their statements is clear. 
Referring to piroplasmosis of cattle in Europe they write “die wohl 
identisch ist mit dem Texasfieber in Amerika und dem Kiistenfieber in 
Ostafrika” and in a footnote we read that “Nuttal und andere haben 
Trypanrot und Tryganblau (sic) bei Piroplasmose der Rinder erfolglos 
angewendet.” It would take some ingenuity to compress more errors 
into as few words. European Redwater or Piroplasmosis is not identical 
with Texas Fever and East Coast Fever is in no way related to either 
of these diseases. Nuttall and Hadwen and others have demonstrated 
in the most convincing manner that Trypanblue does cure piroplasmosis 
in cattle as well as in dogs and horses. 
The statements regarding the curative effects of tryposafrol in 
some of the diseases above enumerated are based on insufficient data. 
A single case of Leishmaniasis successfully “ treated” cannot be accepted 
as evidence, it may have been a case of spontaneous recovery. The 
reports on the curative effects in bovine piroplasmosis possess no value 
since we know how frequently cattle recover anyhow from the European 
disease (due to Piroplasma divergens) and there is no evidence that the 
veterinarians who tried the dye were competent to form an opinion or 
that they made any observations of an accurate character following the 
methods laid down by Nuttall and Hadwen in 1909 (Parasitology, n, 
236-266). The methods used by the latter authors are essential when 
it is desired to test the efficacy of a purported remedy for piroplasmosis 
and it is well known how fallacious may be the conclusions of the ordinary 
veterinary clinician. When the results obtained with tryposafrol on 
piroplasmosis dogs in Cambridge proved negative, it was assumed that 
the like would hold for bovine piroplasmosis because the only drug 
which cures both of these diseases is trypanblue as demonstrated by 
ample clinical and experimental evidence collected before and after 
the discovery of the curative effects of the dye by Nuttall and Hadwen. 
In view of the wide claims made by Brieger and Krause and the 
contrary results obtained by other authors it became necessary to carry 
out further experiments with the dye, especially on guinea-pigs infected 
with Nagana, so as to determine the effects of tryposafrol under similar 
experimental conditions to those reported by Brieger and Krause. In 
March 1914, one of us (G. H. F. N.) visited Berlin and had occasion to 
consult with representatives of the Aktien-Gesellschaft fur Anilin- 
