Gf. H. F. Nuttall and E. Hindle 
225 
Experiments in the treatment op Piroplasmosis in Dogs. 
Five dogs, on 14. v. 1914 (day 1), were inoculated subcutaneously 
with 5 c.c. of defibrinated blood containing Piroplasma canis. One of 
these dogs (dog A) served as a control, and four dogs (dogs Nos. 1-4) 
were subjected to treatment with novo-tryposafrol ; the first dose was 
mixed with the food, the subsequent doses were suspended in water 
and given directly per os. Treatment began on the day of inoculation. 
The faeces showed the presence of the dye on the third or fourth day. 
Dog 1. Fox terrier, weight 10-5 lbs. 
Temp. ° F. 
Pay 
a.m. 
p.m. 
Treatment 
1 
The dog was inoculated 
0-05 g. novo 
-tryposafrol 
2 
o-i 
it 
6 
1034 
102-6 
Fever began; parasites found in dog’s blood 
7 
105 
104-6 
0-2 
tt 
8 
104-8 
105 
Weight 9-5 lbs. 
0-4 
tt 
9 
103-5 
104-6 
0-4 
9t 
10 
103-2 
102-2 
Dog not feeding 
0-4 
tt 
11 
101 
98-2 
Temperature falling; anaemic 
0-4 
tt 
12 
Weight 8-5 lbs. Dog died of piroplasmosis 
Dog 2. Terrier, weight 14 lbs. 
Temp. °F. 
Day 
a.m. 
p.m. 
Treatment 
1 
The dog was inoculated 
0-05 g. novo-tryposafrol 
2 
o-i 
6 
102-6 
103 
Fever began; parasites found in dog’s blood 
7 
102-2 
0-2 
103-8 
8 
103-4 
103-8 
Dog not feeding 
04 „ „ 
9 
103 
Dog very weak, anaemic. Died from piro- 
0-4 
plasmosis 
