228 
Tryposafrol 
to be equally useless in the treatment of bovine piroplasmosis when it 
has received a scientific trial in competent hands. 
In view of the negative results obtained by ourselves and other 
independent investigators, working especially with trypanosomiasis, we 
conclude that the value of tryposafrol or novo-tryposafrol as a remedy 
for any of the diseases enumerated by the authors is open to grave doubt 
since the chief claims as to its efficacy were based on experimental results 
which the authors state that they obtained with Nagana. 
REFERENCES RELATING TO TRYPOSAFROL. 
Brieger, L. (29. vii. 1912). Chemotherapie bei Trypanosomeninfektion (Trypano¬ 
soma brucei) nach Verabreichung per os. Berlin. Min. Wochenschr. xlix, 1453- 
1455. 
- (n. 1913). The chemical therapeutics in Trypanosomes Infection after delivery 
through the mouth. Journ. State Med. xxi, 115-117. (The same as the fore¬ 
going. The title is however somewhat original.) 
Brieger, L. and Kratjse, M. (8. i. 1912). Zur medikamentosen Bekandlung der 
kunstlichen Trypanosomen-infektion ( Tryp. brucei). Berlin. Min. Wochenschr. 
xlix, p. 60. 
- (19.1.1914). Neues iiber Tryposafrol und Novotryposafrol. Ibid. LI, 101-103. 
Lgrz, R. (ix. 1913). Ein Mittel von L. Brieger und M. Krause zur Behandlung der 
Trypanosomen im menschlichen Organismus. Arch. f. Schiffs- u. Tropen- 
Hygiene, xvii, 636-640. 
Mouchet, R. and Dubois, A. (in. 1914). Essais therapeutiques dans la Trypano- 
somiase humaine. Beihefte z. Arch. f. Schiffs- u. Tropen-Hygiene, vin, Beiheft 
3, pp. 5-36. 
Nuttall, G. H. F. (25. vr. 1915). Experimental Drug Treatment of East Coast 
Fever of Cattle. Parasitology, vm, 56-87, 1 chart. (See especially pp. 57, 
61-63, 86 in relation to tryposafrol.) 
Rietz, H. (28. vn. 1913). Chemotherapeutische Versuche mit “Trypasafrol.” 
(Zum Teil nach Versuchen von Frl. F. Leupold.) Berlin. Min. Wochenschr. 
l, 1387-1389. 
Werner, H. (iv. 1914). Trypasafrol und Trixidin bei menschlicher Trypanosomiasis. 
Arch. f. Schiffs- u. Tropenkr. xvm, 246-248. 
