2 
Er. McKinney called the meeting of the Large-Scale Review Vtorking Group to 
order at 9:15 a.m. on Cctober 26 , 1982. Dr. McKinney asked the working group 
to consider the minutes of the June 29, 1982, meeting. He suggested a 
clarification in those minutes; the change would more clearly identify the 
Centers for Disease Control/National Institute for Occupational Safety and 
Health (CDC/NICSII) Working Group on Medical Surveillance when that working 
group was mentioned. Hr. Iblin moved acceptance of the minutes of the June 
29, 1982, meeting as modified. Mr. Barbeito seconded the motion. 'The minutes 
were unanimously accepted by voice vote. 
Proposal to Amend Section VII-D-6 of the Physical Containment Recommendations for 
Large-Scale Uses of Organises Containing Recombinant DMA Molecules 
Dr . flcKinney said that the Large-Scale Review Vtorking Group had received a 
request from Mr. Richard F. Geoghegan of E. I. Dupont de Nemours and Company to 
revise Section VII-D-6 of the Physical Containment Recommendations for Large- 
Scale Uses of Organisms Containing Recombinant DHA Molecules (45 FR 24968). 
Section VII-D-6 currently reads as follows: 
"VII-D-6. A closed system used for the propagation and growth 
of viable organisms containing recombinant ENA ir ecules shall 
be operated so that the space above the culture level will be 
maintained at or slightly below atmospheric pressure." 
Dr. McKinney said the language of Section VII-D-6, ( P3-LS level containment) 
would minimize the potential for "blow out" if seal failure or 9ome other 
failure in equipment above the vessel's head space occurred. 
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