15 
Er. Berns pointed out that institutions receiving NIH funds, such as universities 
or small businesses, vhich must comply with the Guidelines, are required to 
follow the Large-Scale Recommendations. He felt including the Recommendations 
in the Guidelines might facilitate compliance by these institutions. 
Dr . Iblin noted that the Guidelines have been substantially revised sinoe the 
Large-Scale Recommendations were issued in 1980. The latest revision attempted 
to include as much information in the Guidelines as possible so as to aid IBCs 
in their oversight function. In light of this trend, she suggested it might be 
logical to incorporate the Large-Scale Recommendations into an Appendix. 
Dr. Berns noted that the Working Group on Revision of the Guidelines had been 
established to periodically review the Guidelines. He suggested that the Large- 
Scale Review Working Group forward the proposal to incorporate the Large-Scale 
Reccrrmendations into the Guidelines to the Working Group on Revision of the 
Guidelines for consideration. 
Dr. Berns then called the attention of the working group to Er. Waitz' proposal 
to modify Sections VII-B-1, VII-C-1, and VII-D-1 of the Physical Containment 
Recanmendations for Large-Scale Uses of Organisms Containing Reconbinant CHA 
Molecules. Er. Berns pointed out that the proposed language would introduce a 
very significant modification into the language by stating that the system 
should be designed to reduce the "potential" for escape. The current language 
in Sections VII-C-1 and VII-D-1 reads "is designed to prevent the escape." 
Dr. Waitz replied that his primary concern in making this request is to 
modify the definition of a closed system. Dr. Waitz said he requested this 
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