22 
Dr. Landy asked which cells in the human body have MSH receptors. 
Cr . Martin said every melanocyte in the skin has these receptors; 
melanocytes compose about five percent of the skin cells. Dr. Murphy 
said other cell types have low level MSH receptors . Dr. Be ms asked if 
A CIH and MSH cross-react. Dr. Martin replied that they did. 
Dr. King Holmes moved approval for the experiments as described in the 
proposal at P4 containment at the FCRF. Dr. Nightingale seconded. By 
a vote of thirteen in favor, none opposed, and no abstentions, the 
motion was approved. 
Dr. Be ms asked how the data generated by the experiments will be reviewed 
before material is permitted to leave the P4 facility. Dr. McKinney 
suggested that the ad hoc Working Group on Tbxins review the data. 
Their recommendation could be acted upon by NIH without action necessary 
by the full RAC, although a report of the Working Group recommendations 
should be sent to the RAC. He so moved. Dr. Landy seconded the motion. 
By a vote of thirteen in favor, none opposed, and no abstentions, the 
motion was approved. 
X. FUTURE MEETING DATES AND ADJOURNMENT 
Dr. Gartland said the next RAC meeting would be scheduled for late March or 
early April 1983. Dr. Nightingale asked if a June meeting were planned. 
Dr. Gartland replied that the subsequent meeting would be scheduled to occur 
about four or five months after the spring meeting. 
Dr. Nightingale asked about the status of the poll on IBC fu-iction. 
Dr. Gartland replied that a memorandum had been sent to the IBC chairpersons. 
Dr. Holmes suggested that RAC might wish to reconsider the premises under 
which shotgun cloning is permitted in view of the decision concerning the 
cloning of the Shiga-like toxin gene. 
The meeting was adjourned at 4:00 p.m. , October 25, 1982. 
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