CONTENTS 
Federal Register of September 22, 1982, announcing proposed 
actions to be considered at a meeting of the Recombinant DNA 
Advisory Ccmmittee (RAC), October 25, 1982, and announcing a 
meeting of the RAC Large-Scale Review Working Group, 
October 26, 1982 1 
Memorandum of October 1, 1982, soliciting comments on revised 
guidelines for research involving recombinant DNA molecules 4 
Minutes of the RAC meeting, October 25, 1982 5 
Minutes of the RAC Large-Scale Review Working Group Meeting, 
October 26, 1982 38 
Federal Register of December 7, 1982, setting forth a proposed 
second annual update of the program to assess the risk of 
recombinant DNA research 57 
Federal Register of January 10, 1983, prcmulgating actions 
reccmmended at the RAC meeting, October 25, 1982 64 
Minutes of the RAC Working Group on Revision of the Guidelines 
meeting, January 21, 1983 68 
Federal Register of March 4, 1983, announcing proposed actions 
to be considered at a meeting of the RAC, April 11, 1983 77 
Minutes of the RAC meeting, April 11, 1983 85 
Federal Register of April 15, 1983, prcmulgating an action 
recommended at the RAC meeting, October 25, 1982 . 126 
Federal Register of June 1, 1983, prcmulgating actions 
recommended at the RAC meeting, April 11, 1983 128 
Federal Register of June 1, 1983, revised NIH Guidelines 135 
Minutes of the RAC Working Group for Development of Response 
to President's Commiss ion's Report on Ethical and Social 
Issues meeting, June 24, 1983 162 
Federal Register of August 16, 1983 announcing proposed actions 
to be considered at a meeting of the RAC, September 19, 1983 181 
[v] 
