DEPARTMENT OF HEALTH AND HUMAN SERVICES 
PUBLIC HEALTH SERVICE 
NATIONAL INSTITUTES OF HEALTH 
RECOMBINANT DNA ADVISORY COMMITTEE 
WORKING GROUP ON REVISION OF TOE GUIDELINES 
MINUTES OF MEETING 
JANUARY 21, 1983 
The Working Group on Revision of the Guidelines was convened at 9:00 a.m. 
on January 21, 1983, in Building 31, Room 7A24, at the National Institutes 
of Health, 9000 Rockville Pike, Bethesda, MD 20205. The meeting was open 
to the public. Dr. Elena Nightingale was chairperson. 
Working Group members present for all or part of the meeting were : 
Susan Gottesman, NIH; Malcolm Martin, NIH; John Scandalios, North Carolina 
State University; Sue Tblin, Department of Agriculture; and Elizabeth Milewski, 
NIH (Executive Secretary). 
Other NIH staff present were : 
William Gartland, NIH. 
Call to Order and Opening Remarks. 
Dr. Nightingale, chairperson, called the meeting to order at 9:10 a.m. She 
said the agenda would cover several topics: 
(1) agricultural concerns, e.g., what constitutes dissemination into 
the environment for plants; 
(2) a review of the letters received from Institutional Biosafety 
Committee (IBC) chairpeople concerning IBC function; 
(3) the desirability of expediting reviews of proposals between 
RAC meetings and if so, how; 
(4) a proposal to incorporate the Physical Containment Recommendations 
for Large-Scale Uses of Organisms Containing Recombinant DNA 
Molecules into the Guidelines as an Appendix; 
(5) the status of Recombinant TWA Advisory Committee (RAC) sub- 
committees and working groups; and 
(6) the current description of P4 physical containment. 
