8 
replied that procedure is reasonable when Eh coli K-12 and S. cerevisiae host- 
vector systems are used. He said all procedures involving animals should 
probably be assigned to the glove box . The working group agreed that language 
providing greater flexibility in use of the P4 facility should be introduced 
into Appendix G-II-D. This language should appear in the Federal Register for 
a period of comment. 
Dr. Nightingale asked if the working group felt the periodicity of working 
group meetings was appropriate. The group agreed that twice yearly meetings 
between RAC meetings was an appropriate schedule for the Working Group on 
Revision of the Guidelines. 
The meeting was adjourned at 12:10 p.m. 
Respectively submitted, 
if itr$ 
Date' 
Executive Secretary 
I hereby certify that, to the best of 
my knowledge, the foregoing Minutes are 
accurate and complete. 
(s 1^5*3 
Date 1 
Elena Nightingale, Ph.D. ,>M.D. 
Chairperson 
Working Group on Revision of the Guidelines 
of the Recombinant DNA Mvisory Committee 
T7S1 
