5 
I. CALL TO ORDER AND OPENING REMARKS 
The Chairman, Dr. Kenneth Berns, called the meeting to order at 9:00 a.m., 
on April 11, 1983. He introduced the newly appointed members of the 
committee: Dr. Royston Clcwes of the University of Texas at Dallas; 
Dr. John McGonigle of Santa Monica, California; and Dr. Susan Gottesman of 
the National Cancer Institute, National Institutes of Health. Dr. Berns 
said two newly appointed members could not attend the April 11 meeting. 
They are Dr. Wolfgang Joklik of Duke University Medical Center and Dr. Mark 
Mills of Vincennes, Indiana. Dr. Berns welcomed the newly appointed 
members and wished them success in their tenure on the RAC. 
II. MINUTES OF THE OCTOBER 25, 1982, MEETING 
Dr. Berns called on Dr. Harris to review the draft minutes (tab 1105) of 
the October 25, 1982, RAC meeting. Dr. Harris said the draft minutes are 
substantively correct. 
Dr. Nightingale said a sentence in Section III, CDC/NIOSH Draft Report 
on Medical Surveillance , is incomplete. The sentence reads: 
"Dr. Nightingale said she could not determine if the report merited 
publication ard, thus, could not make a recommendation on whether 
the CDC/NIOSH report should be published in the Recombinant DNA 
Technical Bulletin . " 
She said the reason she could not make a recommendation concerning publica- 
tion was because she did not know the editorial policy of the journal. She 
asked that this be clarified. 
Dr. Maas said a correction should be made in Section VIII, Part A, Request 
to Clone a Toxin Gene from E. coli , where Shiga toxin is described as 
being "erdotoxic." Dr. Maas said Shiga toxin is not "endotoxic," rather 
it is "enterotoxic" in that it causes fluid release from the jejunum. It 
was also noted that "Shiga" should be capitalized. 
Dr. Harris moved acceptance of the minutes as amended. Dr. Landy seconded 
the motion. By a vote of fifteen in favor, none opposed, and one absten- 
tion, the minutes were accepted. 
III. REPORT ON SOCIAL AND ETHICAL ISSUES OF GENETIC ENGINEERING WITH HUMAN BEINGS 
Dr. Berns called on Mr. Mitchell to begin discussion of the "Report on the 
Social and Ethical Issues of Genetic Engineering with Human Beings" (tabs 
1091, 1092). Mr. Mitchell said this report, entitled "Splicing Life," was 
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