17 
Dr. McKinney said he did not agree with the rationale offered for the 
suggested modification to Appendix G-II-D-2-c. He said the proposed language 
was unclear an! did not reflect the need to operate the P4 facility according 
to standard practices. He suggested (tab 1107) the following wording be 
substituted: 
"In certain circumstances the nature of an experiment may dictate 
the use of a P4 facility without the requirement to employ a host- 
vector system that provides a one-step higher level of biological 
containment. In these cases, the local IBC may approve the experi- 
ment to be conducted using the practices and primary containment 
equipment specified for the P3 level of physical containment. 
Election of either of the alternatives defined in this Appendix 
does not alter the requirement to comply with the other practices, 
procedures, and operational conditions defined for the P4 level of 
physical containment." 
Dr. McGarrity said the rationale for modifying this section is not convincing 
and does not describe the capabilities of a Class III glove box. He added 
that the proposed modifications do not address Appendix G-II-D-l-j, which 
states that material within the Class III cabinet shall be removed frcm 
the cabinet system only after being steam sterilized or contained in a 
nonbreakable sealed container. He said he could not support either the 
proposal published in the Federal Register or the alternative proposed by 
Dr. McKinney. 
No RAC member offered a motion concerning the proposal, and the discussion 
ended. 
VIII. PROPOSED AMENDMENT OF SECTION III-A-2 AND ADDITION OF A NEW SECTION 
III-B-4-c 
Dr. Tolin introduced Dr. Anne Vidaver of the University of Nebraska, an ad 
hoc consultant to the RAC on agricultural issues. Ct:. Vidaver reviewed 
the proposal (tabs 1100, 1101/VI I) to amend Section III-A-2 and add a new 
Section III-B-4-c to the Guidelines. The RAC Working Group on Revision of 
the Guidelines at its January 21, 1983, meeting, recommended that guidelines 
for field testing of plants modified by recombinant DNA be developed for 
consideration at the April 11, 1983, RAC meeting. In response to that 
mandate, the following changes in the Guidelines were proposed and published 
for comment in the Federal Register (48 FR 9441): 
"Section III-A-2 would be modified to read as follows: 
"III-A-2. Deliberate release into the environment of any organism 
containing recombinant DNA except certain plants as described in 
Section III-B-4-c. 
"A new Section, III-B-4-c, would be added as follows: 
ri021 
