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"III-B-4-c. Approval may be granted by the IBC with notification 
bo OREA for growing plants containing recombinant DNA in the 
field under the following guidelines: 
"III-B-4-c-( 1 ) . The plant species is an annual cultivated crop 
of a genus that has no species known to be a noxious weed. 
"III-B-4-c-( 2) . The introduced DNA consists of well characterized 
genes containing no sequences harmful to humans, animals, or plants. 
Antibiotic resistance genes may be introduced as selectable marker 
traits if stable integration into the host ENA is known to occur. 
"III-B-4-c-( 3 ) . The vector consists of DNA from (i) exempt host- 
vector systems (Appendix C); (ii) plants of the same or closely 
related species; (iii) non-pathogen ic prokaryotes or nonpath- 
ogenic lower eukaryotic plants; (iv) plant pathogens if known 
sequences causing disease symptoms have been deleted; or (v) DNA 
constructed from specific sequences of any of the above sources. 
"The DNA may be introduced by any suitable method but if 
co- infect ion or co-cultivation is utilized absence of the 
assisting organism must be demonstrated. 
"III-B-4-c- ( 4 ) . Plants are grown in control access fields under 
specified conditions' appropriate for the plant under study in 
the geographical location. Such conditions should include 
provisions for using good cultural and pest control practices, 
for physical isolation from plants of the same species outside 
of the experimental plot in accordance with pollination charac- 
teristics of the species, and for preventing plants containing 
recombinant DNA from becoming established in the environment. 
Review of the IBC should include an appraisal by scientists 
knowledgeable in the crop, its production practices, and the 
local geographic conditions." 
Dr. Tolin said the proposed language does not provide blanket approval for 
field testing plants. Rather review responsibilities are shifted from the 
RAC to the local IBC when field tests meet certain defined criteria. 
ORDA would be notified before initiation of the experiments. 
Dr. Vidaver commended Drs. Tolin and Scandalios for preparing the preposed 
language. She suggested the word "annual" be deleted from proposed Section 
III-B-4-c- ( 1 ) . Dr. Tolin said the intent was to limit exposure in the 
field to a single season. She agreed the word "annual" should be deleted. 
Dr. Scandalios suggested the language of proposed Section III-B-4-c-(3 ) 
should be modified to read in part: 
"...or (v) chimeric vectors constructed from sequences defined in 
(i) to (iv) above. The DNA may be introduced by any suitable method." 
rm3i 
