21 
As part of her notion, she proposed the following language in Section 
III-B-4-c-(2) be deleted: 
"Antibiotic resistance genes may be introduced as selective marker 
traits if stable integration into the host DNA is known to occur." 
She also accepted in the motion the language proposed by Dr. Fedoroff 
concerning risk assessment to be added to Section III-B-4-c-(4 ) . Some 
additional language modification and the proposed modifications in 
Sections III-B-4-c-(l) and III-B-4-c-(3) would be part of the motion. 
The motion was seconded. 
Dr. Nightingale felt that RAC should not delegate its authority to a working 
group. Dr. Fedoroff agreed. She then offered a substitute motion to incor- 
porate the language of Dr. Gottesman's motion into the Guidelines. However, 
only IBC review and approval would be required, as in the original Tblin- 
Scandalios proposal, with no review by the RAC Plant Working Group. Her 
amendment to require risk assessment language to be included in Section 
IlI-B-4-c-(4 ) would be part of the substitute motion. The substitute 
motion was seconded. 
Dr. Gottesman felt too much responsibility would be assigned to the IBCs 
if Dr. Fedoroff 's substitute motion were accepted. Review by a RAC 
working group would place responsibility midway between RAC and the IBCs. 
She pointed out that proposals involving the cloning of genes for certain 
toxins potent for vertebrates are reviewed currently by a mechanism similar 
to her proposal. 
A motion to call the question passed by a vote of eighteen in favor, none 
opposed, and one abstention. 
By a vote of eight in favor, eleven opposed, and one abstention, Dr. Fedoroff 's 
substitute motion was refused. Dr. Brill abstained. 
The vote was then called on Dr. Gottesman's motion to permit the Plant 
Working Group to grant approval for field testing plants containing recom- 
binant CNA under the following conditions: 
"(1) The plant species is a cultivated crop of a genus that has no 
species known to be a noxious weed. 
"(2) The introduced .DFP\ consists of well characterized genes contain- 
ing no sequences harmful to humans, animals, or plants. 
"(3) The vector consists of DNA (i) from exempt host-vector systems 
(Appendix C); (ii) from plants of the same or closely related 
species; (iii) from nonpathogenic prokaryotes or nonpathogen ic 
lower eukaryotic plants; (iv) from plant pathogens if known 
sequences causing disease symptoms have been deleted; or (v) from 
chimeric vectors constructed from sequences defined in (i) to 
(iv) above. The DNA may be introduced by any suitable method. 
U 06 ] 
