22 
"(4) Plants are grown in control access fields under specified condi- 
tions appropriate for the plant under study and the geographical 
location. Such conditions should include provisions for using 
good cultural and pest control practices, for physical isolation 
from plants of the same species outside of experimental plot in 
accordance with pollination characteristics of the species, and 
for further preventing plants containing recombinant ENA from 
becoming established in the environment. Review by the IBC 
should include an appraisal by scientists knowledgeable of the 
crop, its production practices, and the local geographic condi- 
tions. Procedures for assessing alterations in and the spread 
of organisms containing recombinant DNA must be developed. The 
results of the outlined tests must be submitted to and reviewed 
by the IBC. Copies must also be submitted to the Plant Working 
Group. " 
The language would be incorporated into the Guidelines as an appendix. By 
a vote of twelve in favor, six opposed, and two abstentions, the motion 
was accepted. Dr. Brill was one of the abstainers. 
Dr. Gottesman then moved to modify the language of her motion. She proposed 
deleting item (iv) in Section III-B-4-c-( 3 ) . 
Dr. Vidaver pointed out that deleting item (iv) would restrict research 
with the Ti plasmid, one of the major mechanisms for introducing DNA 
into plants. CP. Martin suggested the word "known" could be deleted. 
Drs. Gottesman, Tolin, and Vidaver then developed the following alternative 
language for item (iv) in Section III-B-4-c-(3): 
"(iv) from plant pathogens only if the sequences causing disease have 
been deleted." 
Dr. Gottesman substituted this language as her proposed motion. Dr. Harvin 
seconded the motion. 
Dr. Martin thought the phrase "use of non-pa thogenic portions or fractions 
of sequences" was more specific than the phrase "disease causing sequences." 
Dr. Tolin said she objected to Dr. Martin's proposed language because 
it would restrict plant research with viral vectors. 
Dr. Candy asked if Cp. Gottesman 's preposed language implies all genes 
necessary to cause disease be deleted or if only one of these genes need 
be deleted. Dr. Fedoroff said only one gene need be removed. Dr. Martin 
said the language is intended to permit use of portions of potentially 
pathogenic organisms or CNAs as vectors; however, only portions which do 
not cause disease are to be used. 
ri07] 
