Attachment II - Page 2 
Table I. The Relative Resistance of Various Animal Species to Shiga Toxin. 
Species 
Relative Resistance 
Rabbit 
1 
Monkey (Macacus raulatta) 
5 
Hamster 
40 
Mouse 
700 
Rat 
5,000 
Guinea pig 
>10,000 
The rabbit is most susceptible to the lethal effect of Shiga toxin. An 
arbitrary value of 1 was assigned for the rabbit. The relative resistance for 
other species was calculated by dividing the species-specific LD^q (expressed 
as toxin dose per kg body weight) by the LD^q for rabbits. 
From J. B. Cavanagh, J. G. Howard, and J. L. Whitby. 1956. The neurotoxin of 
Shigella shigae . A comparative study of the effects produced in various 
laboratory animals. Br. J. Exp. Med. 37 : 272-278 . 
[ 422 ] 
