Yale University 
SCHOOL OF MEDICINE 
333 Cedar Street 
P.0. Box 3333 
Department of Human Genetics 
New Haven, Connecticut 06510 
Nov. 12, 1982 
Dr. William J. Gartland, Jr. 
Office of Recombinant DNA Activities 
National Institutes of Health 
Bethesda MD 20205 
Dear 'Bill, 
Herewith my response to your (undated!) memo concerning the revised 
guidelines, on behalf of Yale's IBC: 
(1) No problems! 
(2) Our largest amounts of time are spent on experiments involving 
whole animals, which require IBC case-by-case approval. 
(3) None of the time spent is inappropriate in amount. 
(4) We have no serious disagreement with any specific containment 
levels . 
(5) As long as NIH insists on promulgating guidelines, the current 
level of stringency seems about right. This level should 
provide public reassurance, without interfering seriously with 
scientific progress. 
( 6 ) Our IBC meets monthly, for two to three hours. 
(7) We are also Yale's Biological Safety Committee; as such, 90 
percent or more of our time is spent on non-recombinant DNA 
matters involving research with pathogenic agents. 
I enclose a copy of our memo to P.I.s, which I thought might interest 
With best regards, 
% 
Edward A. Adelberg 
Professor of Human Genetics 
you. 
Enel. 
[ 543 ] 
