University of Houston 
Central Campus 
Houston, Texas 77004 
Office of Sponsored Programs 
November 17, 1982 
Dr. William J. Gartland, Jr. 
Office of Recombinant DNA Activities 
Building 31, Room 4A52 
Bethesda, Maryland 20205 
Dear Dr. Gartland: 
In response to your memo soliciting comments on the Revised Guidelines for 
Research Involving Recombinant DNA Molecules, our IBC is a general 
Biosafety Committee that meets once every semester or as needed. The 
Committee has found the guidelines to be well thought out and an excellent 
guide. There have been no problems nor any disagreements with RAC's 
actions. 
As chairperson of the Committee, I would like to suggest that the RAC 
publish a summary or a table that would simplify determination of the physical 
and biological containment requirements. For example, a table showing the 
DNA source, vector to be used, host system and the required physical 
containment would be helpful. 
Sincerely yours, 
Michael Klass 
Chairperson, Institutional Biosafety 
Committee, University of Houston 
Central Campus 
MK :ms 
LKB9/L3 
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