INTER-DEPARTMENTAL CORRESPONDENCE 
TEMPLE UNIVERSITY HEALTH SCIENCES CENTER 
Tn Dr - William J. Gartland, Jr. January 7, 1983 
From Chairperson, IBC, Gerald Shockman, Ph.D. .Cjc la jj J4.^4- Vn , 
Subject Res P° nse to questions in memo from Dr. Gartlan d (not dated) 
Comments: Revised Guidelines for Research Involving Recombinant DNA 
Molecules . 
Revised Guidelines - Federal Register, April 21, 1982 
What are the problems with the revised guidelines? 
We have experienced no problems with the current guidelines. 
What things are taking large amounts of time? 
None of the required activities are taking large amounts of time. 
Review of the grant application and the registration document 
do not require large expenditures of time. 
What things are taking inappropriate amounts of time? 
None of the requirements have forced us to take or use inappropriate 
amounts of time. Registration document review and filing are the 
items which require time but not inappropriate amounts. 
In what areas do you disagree with the RAC with regard to containment for 
a particular experiment? 
We have not disagreed with RAC on required or recommended containment. 
If an investigator desires he or she can set up at a higher level 
of containment, usually physical containment. 
In what ways are the guidelines too strigent or too relaxed? 
We have not had any criticisms of the guidelines vis a vis "Too 
strigent or Too relaxed." One investigator after preparing his 
registration document and determining the level of containment 
under the guidelines, felt that he wanted to function at a higher 
level of containment than was required by the guidelines. He made 
his concerns part of his registration document and also made it 
part of his grant application. His operating at a higher level of 
containment will not require any excess of time or additional work. 
How frequently does your IBC meet? 
The IBC of Temple University is called into session as needed, 
therefore, meetings are infrequent. Members are provided information 
and documents for consideration by mail. At the present time all 
research involving Recombinant DNA molecules falls under section 
III-D Exempt experiments, however for internal requirements all PI 
involved in recombinant DNA research are required to submit a 
registration document. 
-continued- 
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