4 . 
Second, Part VII-B-3 mandates that aerosol release be 
prevented during sample collection, material addition and 
culture transfer. The word "prevents" implies an absolute 
condition which at the Pl-LS level is neither realistic nor 
necessary. We suggest that the word "minimizes" be used 
instead. Such a change is consistent with the intent of this 
section of the recommendations. 
Our third comment pertains to formalization of a dialogue between 
industry and the Large Scale Review Working Group. 
Schering, like other industrial organizations, has 
considerable experience in recombinant DNA technology and 
believes that many of us in industry can provide valuable 
assistance and expertise to you as you continue to refine 
the guidelines. We welcome this opportunity and it is our 
hope that communication between this committee and industry 
can be formalized. One mechanism for achieving this would be 
the establishment of a group of advisors which would include 
suitable industry representatives and would be available to 
provide expertise to the Large Scale Review Working Group 
when called upon. Such an advisory group would become a 
primary source of technical expertise that is so vital to the 
work of this committee. We prefer this approach over a 
single industrial representative as it is difficult for a 
single individual to represent the breadth of industrial 
experience. It is also difficult for a single individual to 
represent industry as a whole as opposed to his specific 
organization. 
[ 596 ] 
