Our fourth comment pertains to incorporation of the Large-Scale 
Physical Containment Recommendations into the Guidelines. 
The NIH Guidelines in Section III-B-5 provide that, where 
appropriate, the Large-Scale Physical Containment 
Recommendations be followed for experiments involving greater 
than 10 liters of culture. 
It is our belief that these Recommendations should be 
formalized by incorporating them into the guidelines as a new 
Appendix K. We believe that this is a logical step to take 
and would provide a more efficient mechanism for further 
comment or change to the recommendations. We are concerned 
that failure to take such action may leave a perceived gap in 
the overall regulatory scheme thereby encouraging the 
development of conflicting regulatory requirements, which 
would not be in the best interest of further scientific 
development . 
CONCLUSION 
I thank you, once again, for the opportunity to be included 
in this dialogue on issues of such importance to all concerned. 
We believe we can all benefit by continued communication with 
this committee which has provided and , hopeful ly , will continue to 
provide a forum for discussions regarding large-scale uses of 
rDNA. Industry has become substantially involved in this 
technology and our involvement is likely to grow as we learn more 
about the wide ranging possibilities for its further use. 
[ 597 ] 
