Dr. William J. Gartland, Jr. 
Director, Office of rDNA Activities 
National Institutes of Health 
Page 2 
February 1, 1984 
accidental release of PI organisms have been judged to be 
minimal. The latter point is demonstrated by the 
containment guidelines for PI microbiological laboratories, 
where the lab is not necessarily airtight, aerosols are 
generated in the open lab, unrestricted ingress and egress 
of personnel is permitted, etc., with the accepted 
possibility that these PI organisms may be transported 
outside the lab. Thus, we feel that more stringent 
guidelines for PI growth of plants is unnecessary and 
inappropriate. We support the remainder of the proposal, 
with the sentence referring to positive and negative air 
pressure deleted. 
We trust you will give full consideration to the above positions 
when the RAC meets on February 6. 
Sincerely, 
David J. Glass 
Director 
Patent and Regulatory Affairs 
DG/das/034 
[647] 
