a 
May 23, 1984 
Director, Office of Recombinant DNA Activities 
Page Two 
We endorse the proposed amendments to Appendix G of the guidelines and 
would propose that the following statement be added to Section III-D-4 In 
order to emphasize the need for appropriate biosafety level containment 
for exempt experiments: 
Although these experiments are exempt under the guidelines, It Is 
recommended that they be performed at the appropriate biosafety level 
for the host or recombinant organism (for biosafety levels see 
"Biosafety In Microbiological and Biomedical Laboratories"). 
Sincerely, 
^ John H. Keene, Dr. P.H. 
Corporate Biohazard Control Officer 
CSW/JHK/pc 
[ 684 ] 
