Genentech, Inc. (Genentech) hereby submits comments on the 
recommendations of the report "The Environmental Implications of 
Genetic Engineering prepared by the staff of the Subcommittee 
on Investigations and Oversight of the Committee on Science and 
Technology of the United States House of Representatives (the 
Gore Report) The recommendations were published in the Federal 
Register on April 24, 1984 (49 Fed. Reg. 17682). 
I. INTRODUCTION 
A . Genentech, Inc. 
Genentech is a biotechnology company, principally concerned 
with the manufacture of human and animal pharmaceutical pro- 
ducts. It has genetically engineered several important products 
for medical and veterinary use: TPA, a substance that dissolves 
blood clots which cause heart attacks; gamma interferon, an 
anti-cancer and anti-viral agent; bovine interferon, an anti- 
viral and immunomodulat ing agent; human insulin; human growth 
hormone; and most recently, Factor VIII, an essential blood 
clotting factor missing in hemophiliacs. Genentech has no plans 
to release organisms deliberately into the environment. 
B . Background of Industry 
Industrial applications of genetic engineering clearly have 
great potential to benefit mankind; it is reasonable to expect 
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