11 
of culture) uses of organisms containing recombinant DNA mole- 
cules. ]JL/ Also, Institutional Biosafety Committees (IBCs) 
are specifically mandated to determine appropriate containment 
levels for each situation. 12/ Additionally, the Guidelines 
prohibit, without the express prior approval by NIH and an IBC, 
following a Recombinant DNA Advisory Committee (RAC) review, 
formation of DNA with genes for the biosynthesis of toxic mole- 
cules or introduction of new antibiotic resistant genes. 13/ 
Moreover, industry does voluntarily comply with the Guide- 
lines. Convincing reasons exist for voluntary industrial 
compliance. The Guidelines are founded on scientific risk 
assessment and subjected to review and change based on expert 
evaluation that has demonstrated consistent sound judgment. 
Industry would discourage the possibility of stricter, anti- 
industrial and ill-founded regulation and, therefore, has 
significant incentive to continue to comply with the existing 
scheme. Additionally, industry executives are aware that a 
shift in public acceptance might result not only in increased 
regulation but also in sudden death for the infant industry. 
11/ 
48 
Fed. 
Reg. 
at 
12/ 
Id. 
at 
24559 . 
13/ 
Id. 
at 
24557- 
-58. 
[ 711 ] 
