Date 
From 
Subject 
To 
DEPARTMENT OF HEALTH & HUMAN SERVICES 
Public Health Service 
National Institutes of Health 
JUN 71984 
Director, NIH 
Memorandum 
Delegation of Authorities Under the NIH Guidelines for Research 
Involving Recombinant DNA Molecules 
Director, NIAID 
By previous memoranda of July 12, 1979, and June 22, 1981, the Director, 
NIH, delegated to the Director, NIAID, all responsibilities of the 
Director, NIH, specified in the NIH Guidelines for Research Involving 
Recombinant DNA Molecules. By this memorandum I am revoking this 
delegation in regard to promulgating the final decision of the Director, 
NIH, on "major actions" as defined in Section IV-C-l-b-(l) of the 
Guidelines (48 FR 24561-24562). Before a final decision by the Director, 
NIH, such "major actions" require review by the NIH Recombinant DNA 
Advisory Committee (RAC) , and publication in the Federal Register 
for public comment at least 30 days prior to the RAC meeting at which 
they are considered. 
All other responsibilities of the Director, NIH, specified in the NIH 
Guidelines for Research Involving Recombinant DNA Molecules, including 
the publication in the Federal Register for comment of items to be 
considered by the RAC, remain delegated to the Director, NIAID. 
Wyngaarden, M.D. 
[725] 
