DAVID CERNA-PHYSIOLOGICAL ACTIONS OF SPARTEINE. 
49 
and muscles retain their excitability for a considerable time. No post¬ 
mortem lesions of any consequence are observed. I may say, in passing, 
that in my experiments I have employed the sulphate of sparteine-'Mevok, 
free from all impurities. 
Fig. A. 
Tracing II.—(Normal).—Dog weighing 7.5 kilos. Injected intravenously 0.01 
gramme of sparteine sulphate. Upper line represents respiratory movements; 
middle line the blood-pre3Sure and pulse; lower line abscissa and time in seconds. 
The following general experiments are given as illustrations: 
Experiment I; Medium sized frog. Gave subcutaneously at 2 p. m., 
0.001 gramme of sparteine. 2:20, animal is restless, and breathes rap¬ 
idly; muscular twitchings are observed, and reflexes appear increased. 
2:45, decided increase in reflex action, but movements are somewhat 
slow. 3:10, clonic and tetanic convulsions, alternately, are developed; 
respirations irregular and labored; placed on its back, frog lies motion¬ 
less, with occasional twitchings and convulsive movements. 3:30, same 
condition of quietude; the reflexes are now slowly elicited on mechanical 
irritation. 3:50, respiration stops; animal apparently dead. Opened 
chest, and found heart still beating slowly but vigorously. 4:30, the 
organ ceased to act, being arrested in diastole. Muscles and nerves 
intact. 
Experiment II: Frog, weight 32 grammes. Injected, hypodermati- 
cally, 0.0015 gramme at 12:30 p. m. 12:45, batrachian jumps about 
lively; respirations rapid, much restlessness, with decided increase of re- 
