50 
TRANSACTIONS OF THE TEXAS ACADEMT OF SCIENCE. 
flexes. 1:05, frog quiet; voluntary movements are sluggish, but the 
reflex activity continues above normal, as shown by mechanical irrita¬ 
tion. 1:10, a slap on the table produces convulsions in the frog; the 
breathing is now very slow, and, let alone, the animal has a tendency to 
assume a condition of stupor. 1:40, tetanic convulsions occur, and after¬ 
ward the respiration ceases. The heart continues to beat, however; this 
organ ceasing to act fifteen minutes later. After death, both nerves and 
muscles responded to electrical stimulation. 
Fig.JB. 
Tracing II.—The same, 5 minutes afterwards. 
Experiment III: Dog, weight five kilos. Exposed the external jugular 
vein and injected into it, well diluted and slowly, 0.01 gramme of sul¬ 
phate of sparteine, at 10:32 a. m. 10:40, animal exceedingly restless; 
runs about and pants as if tired. The heart beats rapidly; tremors are 
observed. 11:15, lies down in a corner of the room and remains quiet, 
with occasional startings. 11:25, excitement has returned. 11:30, 
animal quiet again. Dog finally recovered and was used for another 
experiment. 
In similar experiments, large amounts of the drug produced from the 
beginning a stage of general depression, this being gradual but marked 
till the occurrence of death. For a more clear and better understanding 
of the subject, I will take up the study of the actions of the drug on the 
different systems, seriatim. 
