DAVID CERNA—PHYSIOLOGICAL ACTIONS OF SPARTEINE. 
53 
terminal portions of both sensory and motor nerves is thus destroyed. 
The action must, therefore, be a centric one. 
Experiment VI: A frog, weighing 32 grammes. After the animal was 
pithed, the sciatic nerve of the right side was dissected out carefully, and 
isolated. All the tissues with the exception of the nerve, were ligated, 
and the shock from the operation was allowed to pass off. At 3:10 p. in., 
reflex action was manifested in eight seconds. 3:15, subcutaneous injec¬ 
tion of sulphate of sparteine, 0.0015 gramme. 3:25, reflex action in 4 
seconds in non-protected leg; the same in protected leg. 3:30, reflex 
action in both legs in 3 seconds; convulsions. 3:35, reflex action in 3 
seconds, in both legs. 4:30, reflex action in both legs in 15 seconds. 
Fig. D. 
Tracing II.—The same, 10 minutes after the second injection. 
Shutting off the circulation to the lower extremities, not only by lig¬ 
ating the peripheral vessels, but also by tying the abdominal aorta, does 
not prevent the production of increased reflexes through the action of 
sparteine. The results observed in the following experiment, an example 
of many others performed, are sufficiently self-explanatory. 
Experiment VII: Frog. Ablated cerebrum and then carefully tied 
the peripheral blood vessels and abdominal aorta. Waited for the disap¬ 
pearance of shock. The usual test showed the production of reflexes in 
6 seconds. Five minutes after, an injection of 0.0015 gramme of spar¬ 
teine sulphate was administered subcutaneous^, at 4:20 p. m. 4:28, re¬ 
flex action in 4 seconds. 4:35, reflex action in 2 seconds, followed by 
