DAVID CERNA-PHYSIOLOGICAL ACTIONS OF SPARTEINE. 61 
My experiments in the mammal were divided into four series, as fol¬ 
lows: first, on normal animals; secondly, on animals under the influence 
of curare; thirdly, on dogs whose vagi had been previously divided; 
fourthly, on those in which all nervous connection with the heart was 
destroyed by previous section of both pneumogastrics and the spinal 
cord high up. In these latter instances, as in currarized dogs, artificial 
respiration was employed. After the various operations, which were 
made under an anesthetic, the animal was connected with the recording 
kymograph by the carotid artery, and with Marey’s tambour, by a rubber 
tube and metal canula, this latter being introduced into the trachea. 
Before injecting the drug, the dog was allowed to recover fully from 
the effects of the anesthetic, and thus more or less vitiated results were 
avoided. Ten experiments were made on normal animals, of which I 
only detail the following in tabular form. The accompanying tracings 
also aid materially in illustrating the results obtained. 
. In Experiment XIII, for which a dog weighing 6.5 kilos was used, a 
dose of 0.01 gramme was followed in a few moments by a rise of the 
arterial pressure and an increase of the pulse-rate. Two minutes and a 
half later, both the rate of the cardiac beat and the blood-pressure -were 
still above the normal. Three minutes and a half afterward, while the 
pressure continued high, the pulse-rate began to decline, and convulsive 
movements occurred. The respirations were increased in rate but appa¬ 
rently not in depth. A second dose of 0.02 gramme produced a lowering 
of the arterial pressure to even below the original point, and then both 
the pulse and the pressure descended together till the occurrence of 
death, this taking place from respiratory failure. 
Experiment XIII (Xormal). 
Time. 
Dose. 
Pressure 
Pulse. 
Respira¬ 
tion. 
Remarks. 
(Dog weight 6.5 kilos.) 
m. s. 
grammes. 
m.m. 
p. m. 
p. m. 
0 . 
140 
112 
18 
Xormal. 
5.00 
0.01 
140 
112 
18 
Injection begun. 
5.30 
150 
129 
30 
Injection ended. 
7.30 
150 
130 
. 
Convulsive movements; labored res¬ 
piration. 
11 .00 
154 
114 
30 
11.30 
0.02 
154 
10S 
30 
Injection begun. 
12.00 
154 
93 
18 
Injection ended. 
13.00 
110 
90 
18 
From this on the pulse rate, the 
blood pressure, and the respira¬ 
tion declined gradually till the 
occurrence of death, this taking 
place from respiratory failure. 
A dog weighing 5.14 kilos was employed for Experiment XIV, in 
which a single dose of 0.05 gramme of sparteine was administered. Sim¬ 
ilar results were obtained in regard to the pulse, but there was no rise of 
