DAVID CERNA-PHYSIOLOGICAL ACTIONS OF SPARTEINE. 
63 
0.03 gramme. The pulse behaved differently from the last two experi¬ 
ments. There was no increase in rate—in fact, no change whatever, 
although the rise of the pressure was marked. After the second dose, 
however, the cardiac rate was notabh' diminished notwithstanding the 
increased pressure. Immediately on the ingestion of the fourth dose, 
although the pressure had now descended to even below the normal 
height, there was a sudden increase of the cardiac rate, but only to 153, 
still less than the original number of beats. The pulse soon again de¬ 
creased in rapidity, accompanied with a considerable increase in the size 
of the individual waves. The respiration exhibited a marked irregular¬ 
ity. They were at first diminished in number, and toward the end of 
the experiment increased in rate but not in depth. 
For Experiment XVI I used a dog weighing 5.668 kilos. In this in¬ 
stance both the pulse and the arterial pressure declined after each one of 
the two injections administered. Following the first dose of 0.05 gramme, 
Experiment XVI (Normal). 
Time. 
Dose. 
Pressure. 
Pulse. 
m. s. 
grammes 
m. m. 
p. m. 
0.00 
130 
123 
1 .45 
0.05 
130 
123 
2.15 
110 
114 
3.45 
90 
93 
0.45 
110 
102 
14.15 
120 
96 
16.30 
0.05 
120 
102 
17.00 
100 
93 
18.00 
60 
66 
21.00 
48 
45 
22.30 
30 
60 
24.00 
10 
54 
25.00 
Remarks. 
(Dog-weight 5,668 kilos.) 
One vagus and one crural nerve prepared. 
Small electric current used to produce in¬ 
hibition of heart in ten seconds when ap¬ 
plied to central end of nerve (vagus), and 
in about six seconds when applied to peri¬ 
pheral end. 
Injection begun. 
Injection ended. 
Pulse waves large (18 min.). 
Pulse waves not so large. 
Injection begun. 
Injection ended. 
Pulse waves very large (28 mm.). 
Pulse waves very large, current to vagus, 
either end, caused immediate arrest of 
heart. 
Strong current to crural nerve; no effect on 
pressure; respiration ceases. 
Pulse waves still large, giving evidence of 
prolonged cardiac systole. 
Heart ceased; postmortem showed organ in 
diastole, full of dark blood. 
the pressure, which had fallen from 130 to 90 mm., showed a tendency 
to regain its normal standard, but even after fourteen minutes it only 
marked 120. The second injection of the same amount was followed 
again by a lowering of the pressure, the fall being gradual. When it 
was marking 30 mm., a strong current of electricity applied to ischiatic 
nerve produced no effect whatever on the column of mercury. The pulse- 
