64 
TRANSACTIONS OF THE TEXAS ACADEMY OF SCIENCE. 
rate was depressed also after the first dose, and when it was marking 
only 93 (normal 123), the individual pulse-waves became enormously 
large. Three minutes later, the rate of the heart was 102; in about eight 
minutes it again fell to 96, and once more, in the course of nearly two 
minutes afterward, a rate of 102 was produced. After the second dose, 
the pulse-rate fell again pari passu with the descent of the arterial pres¬ 
sure, the secondary fall being again accompanied with an enormous size 
of the individual pulse-waves. The beats were reduced to 45, and when 
a minute later the action had become a little faster, 60 per minute, both 
ends of the cut vagus were stimulated by the small current of electricity 
used before the ingestion of the drug, and an almost immediate arrest of 
the heart followed. Death of the animal finally occurred from failure of 
the respiration. 
Thus it is seen that the actions of sparteine upon both the arterial pres¬ 
sure and the rate of the pulse, in normal animals, is not by any means 
constant, the effects of the drug being undoubtedly dependent not only 
on the size of the dose administered, but also upon which one of the 
actions predominates. 
As an example of the more constant results obtained in curarized ani¬ 
mals, the following experiment is submitted: 
Experiment No. XVII. Dog-weight 6.91G kilos. 
Time. 
Dose. 
Pressure. 
Pulse. 
Remarks. 
Curarized. 
m. s. 
grammes 
m. m. 
p. m. 
0.00 
140 
84 
10.00 
0.5 
140 
84 
Injection begun. 
10.30 
150 
93 
Injection ended. 
11.30 
110 
75 
13.30 
70 
57 
1G 00 
70 
57 
24.00 
100 
57 
27.00 
140 
81 
30.00 
148 
87 
35.00 
150 
102 
41.00 
0.1 
150 
102 
Injection begun. 
41.40 
100 
69 
Injection ended. 
42.00 
100 
GO 
45.00 
96 
51 
Pulse waves very large (30 mm.). 
48.00 
90 
54 
'54.00 
90 
54 
59.00 
90 
54 
64.00 
80 
51 
Pulse waves still very large. Two more doses 
of 0.01 gramme each were administered 
half hour apart. The same effects were 
noticed as regards blood-pressure and 
pulse. The animal was kept alive by arti¬ 
ficial respiration, and was finally killed 
with curare. 
The following experiments are self-explanatory: 
