INFECTION IN INTERMEDIATE HOST: FALCIPARUM 
207 
serving that malarial psychoses are always 
primarily of the confusional type but may 
be transformed into more protracted forms. 
James also stated that malarial neuras¬ 
thenia, sometimes with accompanying signs 
of physical debility, and psychopolyneuritis 
may be observed. Various neuropathies re¬ 
sulting from focal damage to the brain are 
cited by Mannaberg (1905). He stated that 
motor irritative symptoms were less fre¬ 
quent than degenerative symptoms. The 
duration of these symptoms varied greatly. 
Paraplegias due to spinal cord injury have 
been observed, as have also parasthesias, 
anasthesias, and neuralgias. Most writers 
mention an hepatomegaly that may persist 
for some time after the malarial attack. 
Thayer (1897) was convinced of a malarial 
origin of chronic nephritis and Marchiafava 
and Bignami observed that acute and sub¬ 
acute nephritis developed shortly after 
cessation of a grave malarial infection. The 
latter authors feel that these changes are 
toxic in character. 
