CELLULAR BASIS FOR IMMUNITY IN MALARIA 
249 
for monkeys have found that the large 
mononuclears, which have been variously 
defined to include the larger blood lympho¬ 
cytes, monocytes and small macrophages 
but which consist for the most part of 
monocytes, generally increase in relation 
to segmentation of the parasites and to the 
infection as a whole. This increase reflects 
to a minor extent the cytogenesis of macro¬ 
phages in the organs. 
(4) Reparative proliferations. Many of 
the cellular proliferations in malaria are 
not related to the suppression of the infec¬ 
tion, but are fundamentally reparative. 
Thus, cells are frequently destroyed during 
malaria which may, thereafter, be regener¬ 
ated. This is notably true of erythropoie- 
sis and may occur in the regeneration of 
other tissues, as in the liver. It is also true 
to a greater or lesser extent of lymphoid 
hyperplasia, macrophage proliferation and 
the heterogenic cytogenesis of macrophages 
because these cells, particularly in the perni¬ 
cious infections with P. falciparum, are 
often destroyed by the toxic action of the 
parasites. 
